ABSTRACT
Aim of this research work is to observe and analyze the clinical effect of total thyroidectomy combined with radioactive iodine in thyroid cancer treatment. The 120 thyroid cancer patients treated in our hospital were enrolled as study subjects and assigned to study group [treated with total thyroidectomy and radioactive iodine] and reference group [treated with conventional total thyroidectomy]. The overall treatment efficacy was compared between the two groups. Comparison of overall treatment efficacy of the two groups showed that the study group has superior results to the reference group [P<0.05]. Comparison of incidence of recurrent laryngeal nerve injury in the two groups revealed no significant differences, P>0.05. However, in life quality assessment, the study group was significantly superior to the reference groupin terms of physiological function, psychological function, social function, and overall life quality scores, P<0.05. Total thyroidectomy combined with radioactive iodine can well improve the overall treatment efficiency and enable patients to have higher quality of life at the same time
ABSTRACT
Objective: To evaluate the effects of thyroid cystectomy for primary hyperparathyroidism on immune function
Methods: Ninety-two patients with parathyroid cysts complicated with primary hyperparathyroidism were randomly divided into a treatment group and a control group [n=46]. The treatment group received endoscopic thyroidectomy through the anterior chest wall via the areolar approach, and the control group was treated with conventional open thyroidectomy
Results: The two groups had similar immune function indices as well as thyroid hormone, serum calcium and phosphorus levels before surgery [P>0.05]. After surgery, FT3 and FT4 levels significantly increased in both groups, whereas that of TSH significantly decreased [P<0.05]. The levels of the two groups differed significantly on the postoperative 5[th] day [P<0.05]. NK%, CD3[+]%, CD4[+]% and CD8+%, which significantly fluctuated on the postoperative 1[st] day in both groups [P<0.05], were basically recovered on the postoperative 5[th] day in the treatment group that had significantly different outcomes from those of the control group [P<0.05]. On the postoperative 1[st] and 5[th] days, the treatment group had significantly lower serum calcium level and significantly higher serum phosphorus level than those of the control group [P<0.05]. The surgeries were successfully performed for all patients. During three months of follow-up, the treatment group was significantly less prone to complications such as surgical site infection, recurrent laryngeal nerve injury, parathyroid crisis and hoarseness than the control group [P<0.05]
Conclusion: For treatment of primary hyperparathyroidism, endoscopic thyroidectomy through the anterior chest wall via the areolar approach decreased the incidence rate of complications, as well as promoted the recovery of serum calcium and phosphorous levels, probably by only mildly affecting immune function and thyroid hormone levels
ABSTRACT
Objective: To explore the therapeutic effects of sequential chemoradiotherapy with pemetrexed and cisplatin on locally advanced laryngeal cancer [LALC]
Methods:Fifty LALC patients who were treated in our hospital between January 2010 and January 2012 were selected and randomly divided into an observation group and a control group [n=25]. The two groups were given conventional radiotherapy in the same manner, before which two cycles of chemotherapy were performed. The observation group intravenously infused with 500 mg/m[2] pemetrexed on d1 and 25 mg/ m[2] cisplatin on d1-3, with 28 days as a cycle. The control group was intravenously infused with 25 mg/m[2] cisplatin on d1-3 and 400 mg/m[2] fluorouracil, with 28 days as a cycle. The short-term effects and adverse reactions of both groups were observed after treatment, and their survival was observed by follow-up for five years
Results:The response rate was 84% [21/25] in the observation group and 64% [16/25] in the control group, between which the difference was statistically significant [P<0.05]. The differences in the incidence rates of short-term adverse reactions such as grade III-IV gastrointestinal reactions and bone marrow suppression were not statistically significant between PC regimen [pemetrexed combined with cisplatin] and PF regimen [cisplatin combined with fluorouracil] [P>0.05]. The incidence of long-term adverse reactions such as grade III-IV laryngeal edemas, laryngeal cartilage inflammation and laryngeal cartilage necrosis showed no significant differences between the two groups [P>0.05]. The median survival was 3.3 years after PC chemotherapy and 2.8 years after PF chemotherapy, between which the difference was not statistically significant [P>0.05]. The levels of serum tumor markers significantly decreased after PC and PF treatments compared with those before [P<0.05]
Conclusion:Combining PC chemotherapy with radiotherapy has satisfactory short-term therapeutic effects on LALC, and the resulting adverse effects can be tolerated. Therefore, this strategy is worthy of promotion and application in clinical practice
ABSTRACT
Objective: To evaluate the effects of early enteral micro-feeding on neonatal serum vitamin D levels, and to analyze the application value of glutamine
Methods: One hundred ninty neonates enrolled in intensive care unit were randomly divided into a treatment group and a control group [n=95] that were both given enteral and parenteral nutrition support. Meanwhile, the treatment group was fed formula milk containing 0.3 g/[kg·d] glutamine as enteral nutrition support for 14 days
Results: The weight of the treatment group increased significantly faster than that of the control group did [P<0.05]. The treatment group had significantly higher milk amount and calorie intake than those of the control group [P<0.05], and neonates in the treatment group who reached calorie intake of 50/80/100 kcal/kg/d were significantly younger [P<0.05]. Meanwhile, the treatment group was significantly less prone to feeding intolerance than the control group [P<0.05]. After 14 days of feeding, the serum motilin, gastrin and vitamin D levels of both groups all increased, with significant intra-group and inter-group differences. Such levels of the treatment group significantly exceeded those of the control group [P<0.05]
Conclusion: Supplementing early enteral micro-feeding with glutamine promoted the absorption of neonatal routine nutrients and vitamin D, obviously regulated gastrointestinal hormones, and elevated weight as a result